DC Chemicals · Product datasheet

SBI-797812 — Datasheet

CAT. NO. DC43920

Product page and current package options

ParameterValue
Chemical Name1-[4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)urea
CAS No.2237268-08-3
Synonyms1-(4-((8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)phenyl)-3-(pyridin-4-ylmethyl)urea;1-[4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)urea;SBI-797812
FormulaC19H22N4O4S
M.Wt402.467382907867
SMILESS(C1C=CC(=CC=1)NC(NCC1C=CN=CC=1)=O)(N1CC2CCC(C1)O2)(=O)=O
Purity>98%
Storage0°C (short term), -20°C (long term), desiccated

Biological Activity

SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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