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preQ1 Dihydrochloride — Datasheet

CAT. NO. DC43798

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ParameterValue
Chemical NamepreQ1 Dihydrochloride
CAS No.86694-45-3
Synonyms2-Amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4(3H)-one;B,2HCl-2-Amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4-one;Pre-queuosine1 dihydrochloride;2-Amino-5-(aminomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one dihydrochloride;7-Aminomethyl-7-deazaguanine dihydrochloride
FormulaC7H9N5O
M.Wt179.17926
SMILESNC1N=C2N=CC(CN)=C2C(=O)N1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

preQ1 is a precursor in the biosynthesis of queuosine, a bacterial nucleoside incorporated into tRNA by tRNA transglycosylase. preQ1 binds to an aptamer domain on tRNA that acts as a riboswitch to repress gene expression.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Okada, N., Noguchi, S., Kasai, H., et al. Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction. J. Biol. Chem. 254(8), 3067-3073 (1979).

2. Wu, M.-C., L

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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