DC Chemicals · Product datasheet

Dexmedetomidine hydrochloride — Datasheet

CAT. NO. DC4240

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ParameterValue
Chemical NameDexmedetomidine hydrochloride
CAS No.145108-58-3
SynonymsDEXMEDETOMIDINE HCL;4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride;4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride;DEXMEDETOMIDINE HYDROCHLORIDE;DEMEDETOMIDINE HCL;Dexmedetomidine(Pilot);5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole,hydrochloride;Dexmedetomidine (hydrochloride);(+)-Medetomidine hydrochloride;(S)-Medetomidine hydrochloride;Dexdor;Precedex;UNII-1018WH7F9I;4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride;(S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Hydrochloride;(S)-4-(α,2,3-Trimethybenzyl)-1H-imidazole Hydrochloride;Dexmedetomidine HCl (Precedex);(S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole hydrochloride;1018WH7F9I;Precedex (TN);4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochloride;(S)-4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole hydrochloride;Dexmedetomidine hydrochloride [USAN];5-[(1S)-1-(2,3-dim
FormulaC13H17ClN2
M.Wt236.7405
SMILESCl[H].N1([H])C([H])=NC([H])=C1[C@@]([H])(C([H])([H])[H])C1=C([H])C([H])=C([H])C(C([H])([H])[H])=C1C([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Dexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process. Dexmedetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice. Dexmedetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks. For the detailed information about the solubility of Dexmedetomidine hydrochloride in water, the solubility of Dexmedetomidine hydrochloride in DMSO, the solubility of Dexmedetomidine hydrochloride in PBS buffer, the animal experiment（test） of Dexmedetomidine hydrochloride,the in vivo,in vitro and clinical trial test of Dexmedetomidine hydrochloride,the cell experiment（test） of Dexmedetomidine hydrochloride,the IC50, EC50 and Affinity of Dexmedetomidine hydrochloride, please contact DC Chemicals.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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