Biological Activity
Potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α1 subunit-containing receptors (EC50 values are 2.6, 24, 60 and 77 nM for α1β2γ2, α2β2γ2, α3β3γ2 and α5β2γ2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active. For the detailed information about the solubility of Indiplon in water, the solubility of Indiplon in DMSO, the solubility of Indiplon in PBS buffer, the animal experiment（test） of Indiplon,the in vivo,in vitro and clinical trial test of Indiplon,the cell experiment（test） of Indiplon,the IC50, EC50 and Affinity of Indiplon, please contact DC Chemicals.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.