DC Chemicals · Product datasheet

Mc-VC-PAB-SN38 — Datasheet

CAT. NO. DC40468

Product page and current package options

ParameterValue
Chemical NameMc-VC-PAB-SN38
CAS No.1801838-28-7
FormulaC51H58N8O13
M.Wt991.05
SMILESO=C1OCC(C2=O)=C(C=C(N2CC3=C(CC)C4=C5)C3=NC4=CC=C5O)[C@]1(CC)OC(OCC6=CC=C(C=C6)NC([C@@H](NC([C@@H](NC(CCCCCN7C(C=CC7=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O
Purity>95%
Storage-20°C, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Biological Activity

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs).

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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