CL2-SN-38 (dichloroacetic acid salt) Datasheet | DC39818

CL2-SN-38 (dichloroacetic acid salt) — Datasheet

CAT. NO. DC39818

Parameter	Value
Chemical Name	CL2-SN-38 (dichloroacetic acid salt)
CAS No.	1036969-20-6
Synonyms	CL2-SN-38(DCA)
Formula	C82H106N12O23
M.Wt	1627.81
Parent-moiety SMILES	CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)[C@@]3(CC)OC(=O)OCc1ccc(NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)C3CCC(CN4C(=O)C=CC4=O)CC3)nn2)cc1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Structure and molecular-weight basis	Parent-compound values; dichloroacetate stoichiometry is unspecified (xDCA). The SMILES depicts the parent moiety.
Material form	dichloroacetate (xDCA)

Chemical identity references

Biological Activity

CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.1 CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.