JWG-071 Datasheet | DC39203

JWG-071 — Datasheet

CAT. NO. DC39203

Parameter	Value
CAS No.	2250323-50-1
Synonyms	JWG071;JWG 071
Formula	C34H44N8O3
M.Wt	612.76
SMILES	COC1C(NC2N=C3N(C(CC)C)C4C(C(=O)N(C)C3=CN=2)=CC=CC=4)=CC=C(C(=O)N2CCC(N3CCN(C)CC3)CC2)C=1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].

In Vitro

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

ERK5:88 nM (IC50)

References & source

[1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.