DC Chemicals · Product datasheet

Apostatin-1 (Apt-1) — Datasheet

CAT. NO. DC39045

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ParameterValue
Chemical NameApostatin-1
CAS No.2559703-06-7
SynonymsApt-1;Apostatin-1;Apostatin-1 (Apt-1);s9705
FormulaC19H27N3OS
M.Wt345.5022
SMILESS(C1=NC([H])([H])C([H])([H])N1C([H])([H])[H])C([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Apostatin-1 (Apt-1) is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosi

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

Daichao Xu, Heng Zhao, Minzhi Jin, et al.Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.Nature.Published: 23 September 2020

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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