DC Chemicals · Product datasheet

MG115 — Datasheet

CAT. NO. DC34242

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Parameter	Value
Chemical Name	MG-115
CAS No.	133407-86-0
Synonyms	L-Leucinamide,N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-;(S)-MG115;MG-115;MG-115 (Z-LL-Nva-CHO);Z-Leu-Leu-Norvalinal;benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;MG115 Z-LLnV;MG115;Z-LLnV;Z-LL-NVA-CHO;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;Z-LEU-LEU-NVA-ALDEHYDE;N-CBZ-LEU-LEU-NORVALINAL;MG115, Z-LLnV;N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester;CHEBI:95100;GTPL11639;Cbz-Leu-Leu-norvalinal;CS-0029136;Q27166869;carbobenzoxy-leucyl-leucyl-norvalinal;Curator_000004;EX-A1500B;Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal;DTXSID00432100;J-006370;AKOS040744889;HY-108552;CHEMBL4518490;SCHEMBL2140161;n-benzyloxycarbonyl-l-leucyl-l-leucyl-l-norvalinal;133407-86-0;NCGC00345815-01;Z-Leu-Leu-Norvalinal, >=90% (HPLC), powder;BDBM476985;QEJRGURBLQWEOU-FKBYEOEOSA-N;DA-55451;DTXCID50382929;benzyl N-((2S)-4-methyl-1-(((2S)-4-methyl-1-oxo-1-(((2S)-1-oxopentan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate;G12577
Formula	C25H39N3O5
M.Wt	461.594267129898
SMILES	O=C([C@H](CC(C)C)NC(=O)OCC1C=CC=CC=1)N[C@H](C(N[C@H](C=O)CCC)=O)CC(C)C
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

MG-115(MG 115) is an inhibitor of NFκB in the cytoplasm by acting on IKK or the proteasome.

In Vitro

MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells[3]. MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates[3]. Cell Viability Assay[3] Cell Line: HepG2 cells Concentration: 0.1, 1, 2, 5, 10 μM Incubation Time: 24 hours Result: Dose-dependently decreased cell viability. Inhibited the proteasomal activity, with an IC50 of 2 μM.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

Ki: 21 nM (20S proteasome); 35 nM (26 Sproteasome)[1]

References & source

[1]. Rock KL, et, al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9;78(5):761-71.

[2]. Lopes UG, et, al. p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem. 1997 May 16;272(20):12893-6.

[3]. Kim J, et, al. The proteasome metabolizes peptide-mediated nonviral gene delivery systems. Gene Ther. 2005 Nov;12(21):1581-90.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.