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Nicotinamide riboside — Datasheet

CAT. NO. DC32224

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Parameter	Value
Chemical Name	Nicotinamide riboside
CAS No.	1341-23-7
Synonyms	Nicotinamide ribose;N-ribosylnicotinamid;3-(Aminocarbonyl)-1beta-D-ribofuranosylpyridinium;1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide;Nicotinamide riboside-oxidized form;NRH-oxidized form;Nicotinamide ribonucleoside;NICOTINAMIDE RIBOSIDE;Nicotiamide Riboside;N-ribosylnicotinamide;NR(Nicotinamide Riboside);nicotinamide-beta-riboside;ribosylnicotinamide;1-(beta-D-Ribofuranosyl)nicotinamide;0I8H2M0L7N;Pyridinium, 3-(aminocarbonyl)-1-beta-D-ribofuranosyl-;3-carbamoyl-1-beta-D-ribofuranosylpyridinium;3-Carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium;SRT647;SRT 647;N-ribosyl-nicotinamide;beta-nicotinamide D-ribosi;Nicotinamide riboside chloride;Q3334152;C03150;DTXSID501010039;DB14933;1-b-D-ribosyl-3-Pyridinecarboxamide;nicotinamide riboside;3-(aminocarbonyl)-1-beta-delta-ribofuranosyl-Pyridinium;1-(beta-D ribofuranosyl)nicotinamide;AM84366;CHEMBL438497;UNII-0I8H2M0L7N;1-beta-delta-ribosyl-3-Pyridinecarboxamide;BETA-nicotinamide ribose;Beta-Nicotinamide Riboside;Niagen;SRT-647;SCHEMBL938611;NICOTINAMIDE RIBOSIDE [WHO-DD];3-(aminocarbonyl)-1-beta-d-ribofuranosylpyridinium;Pyridinium, 3-(aminocarbonyl)-1-.beta.-D-ribofuranosyl-;CS-0080934;HY-123033;3-(aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium;nicotinamide ribonucleoside;1341-23-7;CHEBI:15927;TruNiagen;AKOS040740858;1-beta-D-ribosyl-3-Pyridinecarboxamide;nicotinamide ribose;3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1$l^{5}-pyridin-1-ylium;beta-nicotinamide D-riboside;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;Nicotinamide Ribose;Nicotinamide Riboside 99%;3-(AMinocarbonyl)-1beta-D-ribofuranosylpyridiniuM
Formula	C11H15N2O5
M.Wt	255.2472
SMILES	O1[C@]([H])(C([H])([H])O[H])[C@]([H])([C@]([H])([C@]1([H])[N+]1=C([H])C([H])=C([H])C(C(N([H])[H])=O)=C1[H])O[H])O[H]
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1].

In Vitro

Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2.

In Vivo

Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner.

Target

SIRT1

SIRT3

References & source

[1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.