DC Chemicals · Product datasheet

Icatibant — Datasheet

CAT. NO. DC31473

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ParameterValue
Chemical NameIcatibant
CAS No.130308-48-4
SynonymsL-Arginine,D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-;HOE 140;Icatibant;L-Arginine,D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L...;L-Arginine,D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-;H0E-140;HOE I40;HOE-140;S-0765;Icatibant [inn];HOE 140 2ACOH 4H2O;[DES-ARG10] HOE 140;RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R;H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-D-Tic-DL-Oic-Arg-OH;BDBM50403371;AT24149;Icatibant HOE 140;AKOS040741862;JE 049;ICATIBANT [WHO-DD];HOE 140, >=94%;DTXCID901331902;CS-3381;NCGC00390805-02;Hoechst 140;ICATIBANT [EMA EPAR];DB06196;7PG89G35Q7;ICATIBANT [MI];SCHEMBL21495177;icatibant-acetate;ICATIBANT [VANDF];HOE-140 (Icatibant);B06AC02;Q902379;BDBM50406750;icatibanto;Firazyr;EN300-18166877;icatibantum;CHEMBL2028850;HY-17446;UNII-7PG89G35Q7;L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-;(R)-ARGINYL-(S)-ARGINYL-(S)-PROLYL-(2S,4R)-(4-HYDROXYPROLYL)GLYCYL-(S)-(3-(2-THIENYL)ALANYL)-(S)-SERYL-(R)-((1,2,3,4-TETRAHYDRO-3-ISOQUINOLYL)CARBONYL)-(2S,3AS,7AS)-((HEXAHYDRO-2-INDOLINYL)CARBONYL)-(S)-ARGININE;D-Arg-(Hyp3,Thi5,D-Tic7,Oic8)BK;130308-48-4;DTXSID20903963;Icatibant [INN:BAN];HOE140;L-ARGININE, D-ARGINYL-L-ARGINYL-L-PROLYL-TRANS-4-HYDROXY-L-PROLYLGLYCYL-3-(2-THIENYL)-L-ALANYL-L-SERYL-D-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBONYL-L-(2.ALPHA.,3A.BETA.,7A.BETA.)-OCTAHYDRO-1H-INDOLE-2-CARBONYL-;138614-30-9 (Acetate);HOE 140 TFA;BRD-K63772874-001-02-2;BRD-K63772874-001-01-4;DA-64221
FormulaC59H89N19O13S
M.Wt1304.52247023582
SMILESS1C=CC=C1C[C@@H](C(N[C@@H](CO)C(N1CC2C=CC=CC=2C[C@@H]1C(N1[C@H](C(N[C@H](C(=O)O)CCC/N=C(\N)/N)=O)C[C@@H]2CCCC[C@H]12)=O)=O)=O)NC(CNC([C@@H]1C[C@H](CN1C([C@@H]1CCCN1C([C@H](CCC/N=C(\N)/N)NC([C@@H](CCC/N=C(\N)/N)N)=O)=O)=O)O)=O)=O
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Icatibant is a peptidomimetic drug consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors. It has been approved by the European Commission for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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