DC Chemicals · Product datasheet

Dilmapimod (SB-681323) — Datasheet

CAT. NO. DC31346

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ParameterValue
Chemical NameDilmapimod
CAS No.444606-18-2
SynonymsSB681323; SB 681323; SB-681323; GW 681323; GW-681323; GW681323; Dilmapimod.
FormulaC23H19F3N4O3
M.Wt456.42
SMILESO=C1N(C2C(F)=CC=CC=2F)C2C(=C(N=C(N=2)NC(CO)CO)C2C(C)=CC(F)=CC=2)C=C1
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

In Vitro

Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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