DC Chemicals · Product datasheet

NVS-ZP7-4 — Datasheet

CAT. NO. DC30015

Product page and current package options

ParameterValue
CAS No.2349367-89-9
SynonymsNVS-ZP7-4; NVS-ZP7 4; NVS-ZP74; NVSZP7-4; NVSZP7 4; NVSZP74
FormulaC28H28FN5OS
M.Wt501.618227958679
SMILESO=C1NC2C=CC=CC=2C2(CCN(C[C@H](CC3C=CC=CC=3)NC3SC4C(=CC=C(C=4)F)N=3)CC2)N1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells, suggesting a direct interaction between the compound and ZIP7. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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