Cyclic-di-GMP(c-di-GMP) Datasheet | DC28013

Cyclic-di-GMP(c-di-GMP) — Datasheet

CAT. NO. DC28013

Parameter	Value
CAS No.	61093-23-0
Synonyms	CYCLIC DIGUANOSINE MONOPHOSPHATE ( C-DIGMP )3'-Guanylic acid,guanylyl-(3'®5')-,cyclic 3'®5'''-nucleotide;CYCLIC BIS ( 3' → 5' ) DIGUANYLIC ACID;5'''-nucleotide;bis(3',5')-cyclic diguanylic acid
Formula	C20H24N10O14P2
M.Wt	690.41
SMILES	NC1=NC(=O)C2=C(N(C3OC4COP(OC5C(COP(OC4C3O)(O)=O)OC(N3C=NC4C(N=C(NC3=4)N)=O)C5O)(O)=O)C=N2)N1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMS

Biological Activity

Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

STING[1]

References & source

[1]. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57.

[2]. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.