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DG-172 dihydrochloride — Datasheet

CAT. NO. DC24079

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ParameterValue
Chemical NameDG172 dihydrochloride
CAS No.1361504-77-9
SynonymsDG 172 dihydrochloride;DG172 (dihydrochloride);DG-172 dihydrochloride;DG172 2HCl;DG172 dihydrochloride;(Z)-2-(2-bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;(?Z)-2-Bromo-?-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
FormulaC20H22BrCl2N3
M.Wt455.2188
SMILESBrC1=C([H])C([H])=C([H])C([H])=C1/C(/C#N)=C(\[H])/C1C([H])=C([H])C(=C([H])C=1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H].Cl[H].Cl[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

DG-172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC50= 27 nM) and potent inverse agonistic properties; inhibits agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment; down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50= 9.5 nM); orally bioactive.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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