DC Chemicals · Product datasheet

ZM39923 — Datasheet

CAT. NO. DC24070

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ParameterValue
Chemical Name3-benzyl(propan-2-yl)amino-1-(naphthalen-2-yl)propan-1-one
CAS No.273727-89-2
Synonyms1-Propanone,3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-;2-naphtyl 2-(N-isopropyl-N-benzylamino)ethyl ketone;ZM-39923;1-Propanone,3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl);2-(N-isopropylbenzyl)aminoethyl-2-naphthylketone;3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one;ZM39923;3-benzyl(propan-2-yl)amino-1-(naphthalen-2-yl)propan-1-one;NCGC00025126-02;UNII-M0ZX82000S;Lopac-Z-4626;3-((1-Methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-1-propanone;NCGC00016107-09;M0ZX82000S;Lopac0_000844;3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one;DTXSID701017205;1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-;NCGC00016107-01;NCGC00016107-04;3-[benzyl(isopropyl)amino]-1-(2-naphthyl)propan-1-one;HSCI1_000104;NCGC00016107-02;NCGC00016107-03;CHEMBL596674;EN300-18749151;3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-one;SDCCGSBI-0050820.P003;jak3 inhibitor iv;BRD-K40624912-003-02-3;A913285;3-(Benzyl(propan-2-yl)amino)-1-(naphthalen-2-yl)propan-1-one;ZM 39923;1-Propanone, 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-;GTPL5994;SCHEMBL2891331;AKOS030526763;CHEBI:92715;HY-12589A;NCGC00025126-01;CCG-204927;NCGC00016107-14;273727-89-2;CS-4952;BDBM81346;JSASWRWALCMOQP-UHFFFAOYSA-N;NCGC00016107-05;Tocris-1367;FT-0723801;M9440 (Me-3,4-dephostatin)
FormulaC23H25NO
M.Wt331.4507
SMILESO=C(C1=CC=C2C=CC=CC2=C1)CCN(C(C)C)CC3=CC=CC=C3
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2) with IC50 of 10 nM; ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2; alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival; significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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