DC Chemicals · Product datasheet

Disarib — Datasheet

CAT. NO. DC23302

Product page and current package options

ParameterValue
Chemical Name3-((2-(4-chlorobenzyl)-6-(4-bromophenyl)imidazo[2,1-b][1,3,4] -thiadiazol-5-yl)methylidene)-1,3-dihydro-2H-indol-2-one
CAS No.1998149-15-7
FormulaC26H16BrClN4OS
M.Wt547.85
SMILESN1C(=O)/C(=C\C2=C(C3C=CC(Br)=CC=3)N=C3N2N=C(S3)CC2C=CC(Cl)=CC=2)/C2C=CC=CC1=2
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.); is a novel BCL2 inhibitor with a unique mechanism of BCL2 inhibition.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Iyer D, et al. FEBS J. 2016 Sep;283(18):3408-37. 2. Vartak SV, et al. Biochem Pharmacol. 2016 Dec 15;122:10-22. 3. Vartak SV, et al. Biochem Pharmacol. 2017 May 1;131:16-28. doi: View Related Products by Target Bcl-2

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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