Biological Activity
Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM; greatly reduces the late rise in intracellular free Zn(2+) in postischemic CA1 neurons and affords partial protection against ischemia-induced cell death, protects against ischemia-induced death of CA1 neurons in vivo; selectively suppresses the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons, has no effect on AMPA receptors in type I neurons.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
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References & source
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.