Biological Activity
ML-T531 is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM; exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3; significantly potentiates hERG steady-state currents and tail currents in CHO cells at 10 uM, enhances voltage-dependent potassium current amplitudes in the presence of an Iks-specific inhibitor chromanol 293B; potentiates native potassium currents in iPSC-derived cardiomyocytes, shortens the APD90 of LQT1 cardiomyocytes with EC50 of 5.71 uM, normalizes the disease phenotype of cardiomycytes derived from a patient with LQT1.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
References 1. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.