NSC112200 Datasheet | DC22794

NSC112200 — Datasheet

CAT. NO. DC22794

Parameter	Value
Chemical Name	2,5-Dibromo-3,6-dimethyl-2,5-cyclohexadiene-1,4-dione
CAS No.	28293-38-1
Synonyms	NSC 112200
Formula	C8H6Br2O2
M.Wt	293.942
SMILES	CC1=C(Br)C(=O)C(C)=C(Br)C1=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2, promotes proteasomal degradation of EZH2 and inhibits the viability of TNBC cells; NSC112200 is a mixture of 2,5-dibromo-3,6-dimethyl-1,4- benzenediol and 2,5-dibromo-3,6-dimethyl-1,4-benzoquinone.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

EZH2

References & source

1. Zhang P, et al. Cell Rep. 2018 Apr 17;23(3):823-837.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.