DC Chemicals · Product datasheet

Fezolinetant — Datasheet

CAT. NO. DC22664

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ParameterValue
Chemical NameFezolinetant
CAS No.1629229-37-3
SynonymsFezolinetant;83VNE45KXX;ESN364;(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone;Fezolinetant [USAN];GTPL10422;BDBM50112244;WHO 10205;compound 3 [PMID:26191358];SB19658;Q27269455;(4-fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone;Methanone, ((8R)-5,6-
FormulaC16H15FN6OS
M.Wt358.393304109573
SMILESS1C(C2=NN=C3[C@@H](C)N(C(C4C=CC(=CC=4)F)=O)CCN32)=NC(C)=N1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Fraser GL, et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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