DC Chemicals · Product datasheet

Imidazole ketone erastin（IKE） — Datasheet

CAT. NO. DC22092

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ParameterValue
Chemical NameImidazole ketone erastin
CAS No.1801530-11-9
SynonymsImidazole ketone erastin;IKE;Imidazole ketone erastinIKE;ZB1594;BDBM50126162;s8877;3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one
FormulaC35N6O5ClH35
M.Wt655.1426
SMILESClC1C([H])=C([H])C(=C([H])C=1[H])OC([H])([H])C(N1C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C(N2C2C([H])=C(C(C([H])([H])N3C([H])=NC([H])=C3[H])=O)C([H])=C([H])C=2OC([H])(C([H])([H])[H])C([H])([H])[H])=O)C([H])([H])C1([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Imidazole ketone erastin (IKE) s a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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