DC Chemicals · Product datasheet

SU-909 — Datasheet

CAT. NO. DC21710

Product page and current package options

ParameterValue
Chemical Name4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
CAS No.2126749-48-0
SynonymsBDBM50257823;4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide
FormulaC13H10N6O2S
M.Wt314.322499752045
SMILESS(C1C=CC(=CC=1)C1=C2C(C#N)=CNC2=NC(N)=N1)(N)(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066. View Related Products by Target IκB kinase (IKK)

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation