DC Chemicals · Product datasheet

ITX-5061 hydrochloride — Datasheet

CAT. NO. DC21157

Product page and current package options

ParameterValue
Chemical NameITX5061
CAS No.1252679-52-9
SynonymsITX5061;ITX 5061;J4RA8K2Q2A;BCP30784;Q27281205;1-Naphthaleneacetamide, N-(5-(1,1-dimethylethyl)-2-methoxy-3- ((methylsulfonyl)amino)phenyl)-4-(2-(4-morpholinyl)ethoxy)-alpha-oxo-, hydrochloride (1:1);N-[5-Tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl;N-(5-(tert-butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride;N-[5-(1,1-Dimethylethyl)-2-methoxy-3-[(methylsulfonyl)amino]phenyl]-4-[2-(4-morpholinyl)ethoxy]-alpha-oxo-1-naphthaleneacetamide hydrochloride;1-Naphthaleneacetamide, N-(5-(1,1-dimethylethyl)-2-methoxy-3- ((me;ITX-5061 HCl
FormulaC30H38ClN3O7S
M.Wt620.156626224518
SMILESCl.S(C)(NC1=C(C(=CC(=C1)C(C)(C)C)NC(C(C1=CC=C(C2C=CC=CC=21)OCCN1CCOCC1)=O)=O)OC)(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels; inhibits SR-BI-dependent uptake of HDL-CE in transfected cells, decreases the fractional catabolic rate of HDL-CE and reduced its hepatic uptake in mice; inhibits HCVcc and HCVpp infection of primary human hepatocytes and/or human hepatoma cell lines and has minimal effects on HCV RNA replication.

HCV Infection

Phase 2 Clinical

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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