FN1-8 Datasheet | DC21050

FN1-8 — Datasheet

CAT. NO. DC21050

Parameter	Value
Chemical Name	N-[(4-Hydroxyphenyl)methyl]-2,3,5-triphenyl-3,4-dihydropyrazole-4-carboxamide
CAS No.	1419258-63-1
Synonyms	N-(4-Hydroxybenzyl)-1,3,5-triphenyl-4,5-dihydro-1H-pyrazole-4-carboxamide;N-[(4-hydroxyphenyl)methyl]-2,3,5-triphenyl-3,4-dihydropyrazole-4-carboxamide
Formula	C29H25N3O2
M.Wt	447.527706861496
SMILES	O=C(C1C(C2C=CC=CC=2)=NN(C2C=CC=CC=2)C1C1C=CC=CC=1)NCC1C=CC(=CC=1)O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

Gli

References & source

1. Bosco-Clément G, et al. Oncogene. 2014 Apr 17;33(16):2087-97.

2. He B, et al. US Patent No. 7714014. 2010

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.