Biological Activity
A novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
References 1. Zheng FM, et al. Mol Cancer Ther. 2014 Aug;13(8):1991-2003. 2. Long ZJ, et al. Int J Oncol. 2015;46(6):2488-96. 3. Wang LX, et al. Sci Rep. 2016 Nov 8;6:35533. View Related Products by Target Aurora Kinase
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.