DC Chemicals · Product datasheet

A-803467 — Datasheet

CAT. NO. DC2061

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ParameterValue
Chemical Name5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
CAS No.944261-79-4
Synonyms2-Furancarboxamide,5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;A-803467;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 -dimethoxyphenylamide;5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-Furancarboxamide;5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide;A 803467;5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide;5-(4-Chlorophenyl)furan-2-carboxylic acid 3,5-dimethoxyphenylamide;A803467;C19H16ClNO4;339LBH1395;MLS006011118;GTPL5734;AOB2888;HMS3742E19;HMS3656L08;BCP04519;2-Furancarboxamide, 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-;BN0738;ABP001000;s2785;BD
FormulaC19H16ClNO4
M.Wt357.7876
SMILESClC1C([H])=C([H])C(=C([H])C=1[H])C1=C([H])C([H])=C(C(N([H])C2C([H])=C(C([H])=C(C=2[H])OC([H])([H])[H])OC([H])([H])[H])=O)O1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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