DC Chemicals · Product datasheet

MsbA inhibitor 1 — Datasheet

CAT. NO. DC20466

Product page and current package options

ParameterValue
Chemical Name2-(4-chlorobenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
CAS No.52535-76-9
FormulaC16H14ClNO3S
M.Wt335.802
SMILESC12CCCCC=1C(C(O)=O)=C(NC(=O)C1=CC=C(Cl)C=C1)S2
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

MsbA inhibitor 1 is a novel small molecule lipopolysaccharide biogenesis inhibitor, inhibits MsbA, an ATP-dependent flippase that translocates LPS across the inner membrane; causes mislocalization of LPS to the cell interior, inhibits Δ5 strain with MIC of 0.2 ug/ml.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Zhang G, et al. Proc Natl Acad Sci U S A. 2018 May 7. pii: 201804670. View Related Products by Target Bacterial

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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