DC Chemicals · Product datasheet

LXRβ agonist 17 — Datasheet

CAT. NO. DC20439

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ParameterValue
Chemical Name{2-[(2r)-4-[4-(Hydroxymethyl)-3-(Methylsulfonyl)phenyl]-2-(Propan-2-Yl)piperazin-1-Yl]-4-(Trifluoromethyl)pyrimidin-5-Yl}methanol
CAS No.1878259-00-7
Synonyms{2-[(2r)-4-[4-(Hydroxymethyl)-3-(Methylsulfonyl)phenyl]-2-(Propan-2-Yl)piperazin-1-Yl]-4-(Trifluoromethyl)pyrimidin-5-Yl}methanol;LXRbeta agonist 17;BDBM50177015;J3.604.716J;Q27456252;OCC1=C(C=C(C=C1)N1C[C@H](N(CC1)C1=NC=C(C(=N1)C(F)(F)F)CO)C(C)C)S(=O)(=O)C;2-[4-[3-(Methylsulfonyl)-4-(hydroxymethyl)phenyl]-2alpha-isopropylpiperazine-1-yl]-4-(trifluoromethyl)pyrimidine-5-methanol;67S
FormulaC21H27F3N4O4S
M.Wt488.52369427681
SMILESS(C)(C1=C(CO)C=CC(=C1)N1CCN(C2N=CC(CO)=C(C(F)(F)F)N=2)[C@H](C(C)C)C1)(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

A novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold); induces the expression of LXR target genes in vitro and in vivo.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Zheng Y, et al. J Med Chem. 2016 Apr 14;59(7):3264-71. View Related Products by Target Liver X Receptor (LXR)

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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