6-Hydroxy-DL-DOPA Datasheet | DC20297

6-Hydroxy-DL-DOPA — Datasheet

CAT. NO. DC20297

Parameter	Value
Chemical Name	Tyrosine,2,5-dihydroxy-
CAS No.	21373-30-8
Synonyms	Tyrosine,2,5-dihydroxy-
Formula	C9H11NO5
M.Wt	213.187342882156
SMILES	OC(C(CC1=CC(O)=C(O)C=C1O)N)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer[1].

In Vitro

6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

RAD52[1]

References & source

[1]. Chandramouly G, et al. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015;22(11):1491-1504.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.