DC Chemicals · Product datasheet

Citarinostat(ACY-241) — Datasheet

CAT. NO. DC12668

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ParameterValue
Chemical NameCitarinostat
CAS No.1316215-12-9
Synonyms2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide;ACY-241;Citarinostat;2-?[(2-?chlorophenyl)?phenylamino]?-?N-?[7-?(hydroxyamino)?-?7-?oxoheptyl]?-5-?Pyrimidinecarboxamid?e;ACY241;HDAC-IN-2;2-(N-(2-chlorophenyl)anilino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide;441P620G3P;Citarinostat [USAN];Citarinostat (USAN);AK160199;2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide;2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide;5
FormulaC24H26ClN5O3
M.Wt467.9479
SMILESClC1=C([H])C([H])=C([H])C([H])=C1N(C1C([H])=C([H])C([H])=C([H])C=1[H])C1N=C([H])C(=C([H])N=1)C(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(N([H])O[H])=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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