DC Chemicals · Product datasheet

RAS activator compound 1 — Datasheet

CAT. NO. DC12624

Product page and current package options

ParameterValue
Chemical Name(S)-2-amino-N-(1-((5-chloro-1H-indol-3-yl)methyl)piperidin-4-yl)-3-(1H-indol-3-yl)propanamide
CAS No.1579978-17-8
FormulaC25H28ClN5O
M.Wt449.983
SMILESC(NC1CCN(CC2C3=C(NC=2)C=CC(Cl)=C3)CC1)(=O)[C@H](N)CC1C2=C(NC=1)C=CC=C2
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

RAS activator compound 1 is a small molecule RAS activator compound that increases the rate of SOS-catalyzed nucleotide exchange in vitro with EC50 of 14 uM; targets SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, through negative feedback on SOS1 that regulates the interaction between SOS1 and GRB2.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

References 1. Howes JE, et al. Mol Cancer Ther. 2018 May;17(5):1051-1060. 2. Burns MC, et al. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3401-6. View Related Products by Target Ras

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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