Biological Activity
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity; inhibits TEAD transcriptional activity and protein interactions in cells at 5 uM resulted in over 70% reduction in reporter activity; inhibits GBM43 cancer cell viability by 30% at 10 uM, also inhibits TEAD4 transcriptional activity in GBM43 cells.
In Vitro
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In Vivo
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References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.