Biological Activity
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comparable to that of the endogenous agonist PGE2 in cells over-expressing human recombinant EP2 receptors; exhibited tocolytic, anti-inflammatory, and long-acting ocular hypotensive properties consistent with its potent EP2 agonist properties.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
1. Coleman RA, et al. Br J Pharmacol. 2018 Oct 20. doi: 10.1111/bph.14525.
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.