DC Chemicals · Product datasheet

HS-1371 — Datasheet

CAT. NO. DC12045

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ParameterValue
Chemical Name4-(4-Methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline
CAS No.2158197-70-5
SynonymsHS1371;7-(1-(piperidin-4-yl)-1h-pyrazol-4-yl)-4-(p-tolyloxy)quinoline;BCP30268;ZB1501;s8775;BDBM50246489;AK00898249;4-(4-Methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline;HS-1371
FormulaC24H24N4O
M.Wt384.4736
SMILESO(C1C([H])=C([H])C(C([H])([H])[H])=C([H])C=1[H])C1C([H])=C([H])N=C2C=1C([H])=C([H])C(=C2[H])C1C([H])=NN(C=1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

HS-1371 is a potent and ATP-competitive RIP3 inhibitor with an IC50 of 20.8 nM[1].

In Vitro

HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines[1]. HS-1371 can block RIP3 S227 phosphorylation[1]. HS-1371 rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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