DC Chemicals · Product datasheet

MDK7526(Protein degrader 1) — Datasheet

CAT. NO. DC12028

Product page and current package options

ParameterValue
Chemical NameMDK7526(Protein degrader 1)
CAS No.1448189-80-7
SynonymsVH032-NH2 monohydrochloride; VHL ligand 1 monohydrochloride;Protein degrader 1 (hydrochloride);Protein degrader 1 hydrochloride;3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide hydrochloride (1:1);(2s,4r)-1-((s)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;E3 Ligase ligand;VH032;(S,R,S)-AHPC hydrochloride;(S,R,S)-AHPC monohydrochloride
FormulaC22H31ClN4O3S
M.Wt467.025
SMILESO=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.

In Vitro

Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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