DC Chemicals · Product datasheet

Adavivint — Datasheet

CAT. NO. DC11886

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ParameterValue
Chemical NameAdavivint
CAS No.1467093-03-3
SynonymsN-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide;Adavivint;lorecivivint;SM04690;42EK42WHI5;Adavivint [INN];Lorecivivint [USAN];Adavivint; SM04690;Adavivint (SM04690);GTPL9620;BCP30409;WHO 10389;s8761;DB14883;N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl
FormulaC29H24FN7O
M.Wt505.5456
SMILESFC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N=C([H])C2=C1N=C(C1C3C([H])=C(C([H])=C([H])C=3N([H])N=1)C1C([H])=NC([H])=C(C=1[H])N([H])C(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)N2[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.

In Vitro

Adavivint (SM04690) is a potent and selective inhibitor of Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells, and shows no effect on SV40 luciferase reporter. Adavivint enhances aggregation of human mesenchymal stem cells (hMSCs) with an EC50 of 10 nM. Adavivint (30 nM) protects chondrocytes from catabolic breakdown in vitro[1].

In Vivo

Adavivint (0.3 μg) enhances cartilage repair and protection in the rat acute cruciate ligament tear and partial medial meniscectomy osteoarthritis (ACLT + pMMx OA) model[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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