SCB-4380 Datasheet | DC11818

SCB-4380 — Datasheet

CAT. NO. DC11818

Parameter	Value
Chemical Name	Trisodium 3-hydroxy-4-[(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate
CAS No.	915-67-3
Synonyms	SCB 4380;SCB4380
Formula	C20H11N2Na3O10S3
M.Wt	604.473054170609
SMILES	[Na+].[Na+].[Na+].C1=C2C(C=CC(S([O-])(=O)=O)=C2)=C(/N=N/C2=C3C(C=CC=C3)=C(S([O-])(=O)=O)C=C2)C(O)=C1S([O-])(=O)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

SCB-4380 (SCB 4380, SCB4380) is the first potent, selective inhibitor for PTPRZ (protein tyrosine phosphatase receptor-type Z) with IC50 of 0.4 uM against human Z-ICR-catalyzed hydrolysis. SCB-4380 also strongly inhibits PTPRG (IC50=0.4 uM), and shows little inhibition on PTPRA, PTPRM, PTPRS, PTPRB, PTPN1 and PTPN6. SCB-4380 inhibites PTPRZ activity in C6 glioblastoma cells, and suppresse cell migration and proliferation in vitro and tumor growth in a rat allograft model.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

PTPRZ

References & source

1. Fujikawa A, et al. Sci Rep. 2016 Feb 9;6:20473.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.