Biological Activity
AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM; binds to the C terminus of Orai1, directly inhibits calcium influx through the channel and also reduces binding of STIM1; decreased gene expression involved in T cell activation, including IL2, CD27, NFATC1, TNF, TBX21, CSF, ICOS, and CXCR3; effectively blocks T cell activation in vitro and in vivo.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
No in vivo data are provided in the current product source. Contact us for further information.
References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.