JNJ-2408068 Datasheet | DC11647

JNJ-2408068 — Datasheet

CAT. NO. DC11647

Parameter	Value
Chemical Name	2[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-4-methyl-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol
CAS No.	317846-22-3
Synonyms	R-170591;R170591;JNJ 2408068;JNJ2408068
Formula	C22H30N6O
M.Wt	394.523
SMILES	C(CN1C(NC2CCN(CCN)CC2)=NC2=C(C)C=CC=C21)1=NC(C)=CC=C1O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

JNJ 2408068 is a potent RSV (respiratory syncytial virus) inhibitor. JNJ 2408068 significantly inhibits replication of RSV A and B subtypes in the lungs of cotton rats without any evidence of toxicity. The minimum protective dose of JNJ 2408068 appears to be approximately 0.39 mg/kg[1].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

RSV-A

RSV-B

References & source

[1]. Wyde PR, et al. Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res. 2003 Nov;60(3):221-31.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.