DC Chemicals · Product datasheet

Shield-1 — Datasheet

CAT. NO. DC11639

Product page and current package options

ParameterValue
Chemical NameShield-1
CAS No.914805-33-7
SynonymsShield-1 Tosylate;(S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Tosylate;(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-[2-(4-morpholinyl)ethoxy]phenyl]propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate (ACI);Shield 1;Shield-1
FormulaC42H56N2O10
M.Wt748.901453018188
SMILES[C@@H](C1C=C(OC)C(OC)=C(OC)C=1)(CC)C(N1CCCC[C@H]1C(=O)O[C@@H](C1C=CC=C(OCCN2CCOCC2)C=1)CCC1C=CC(OC)=C(OC)C=1)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein[1][2].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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