Laninamivir (CS-8958) Datasheet | DC1108

Laninamivir (CS-8958) — Datasheet

CAT. NO. DC1108

Parameter	Value
Chemical Name	Laninamivir free base
CAS No.	203120-17-6
Synonyms	CS8958
Formula	C13H22N4O7
M.Wt	346.34
SMILES	[H][C@@]1(NC(N)=N)[C@](NC(C)=O)([H])[C@@]([C@](OC)([C@@](O)([H])CO)[H])([H])OC(C(O)=O)=C1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1].

In Vitro

Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1]. Laninamivir is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

IC50: 0.90 nM (N5), 1.83 nM (p09N1), 3.12 nM (p57N2)[1]

References & source

[1]. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.