DC Chemicals · Product datasheet

Desmethyl dabrafenib — Datasheet

CAT. NO. DC11055

Product page and current package options

ParameterValue
Chemical NameN-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
CAS No.1195765-47-9
SynonymsGSK2167542,GSK-2167542,GSK 2167542
FormulaC22H18F3N5O2S2
M.Wt505.534
SMILESC(S(NC1=CC=CC(C2=C(C3C=CN=C(N)N=3)SC(C(C)C)=N2)=C1F)(=O)=O)1=C(F)C=CC=C1F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

1. Bershas DA, et al. Drug Metab Dispos. 2013 Dec;41(12):2215-24.

2. Ouellet D, et al. J Clin Pharmacol. 2014 Jun;54(6):696-706.

3. Suttle AB, et al. J Clin Pharmacol. 2015 Apr;55(4):392-400.

4. Tsai IC, et al. Sci Rep. 2018 Jul 17;8(1):10779.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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