DC Chemicals · Product datasheet

Exo1 — Datasheet

CAT. NO. DC10905

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ParameterValue
Chemical NameEXO1
CAS No.75541-83-2
SynonymsEXO1;methyl 2-[(4-fluorobenzoyl)amino]benzoate;2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER;2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate;2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE;4-FLUORO-BZ-2-ABZ-OME;EOX 1;Exo1, Exocytic Inhibitor 1, 2-(4-Fluoro-benzoylaMino)-benzoic acid Methyl ester;EXOCYTIC INHIBITOR 1;BCP29874;Benzoic acid, 2-[(4-fluorobenzoyl)amino]-, methyl ester;CHEBI:93386;NSC-214045;s6800;CBDivE_001626;2-[(4-FLUOROBENZOYL)AMINO]-BENZOIC ACID METHYL ESTER;Exo 1;NCGC00025310-02;Exo 1, >=98% (HPLC), solid;ML084;CS-0059209;EN300-6492988;SMR000304795;Z27655994;Probes1_000314;AKOS000453340;NSC214045;SR-01000405814-2;DTXSID90893483;FT-0644702;MLS000722799;75541-83-2;Oprea1_575828;Probes2_000388;HSCI1_000065;MS-23874;Probes2_000515;EXOCYTIC INHIBITOR 1;2-[(4-Fluorobenzoyl)amino]benzoic acid methyl ester;461681-88-9;SR-01000405814-1;methyl2-[(4-fluorobenzoyl)amino]benzoate;Probes1_000309;HMS3428E09;HMS3268K08;HMS3676L04;2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester;EU-0002175;SCHEMBL4459274;HY-112670;SR-01000405814;HMS2757J19;methyl 2-(4-fluorobenzamido)benzoate;BRD-K78633253-001-04-6;Exo-1;Q27165089;CHEMBL250428;Exo-1; Exo 1;BRD-K78633253-001-01-2;HMS3412L04;NCGC00025310-01;Probes1_000442;DB-051358;GLXC-02305;STK514439;DA-73279;BRD-K78633253-001-10-3;methyl 2-{[(4-fluorophenyl)carbonyl]amino}benzoate;G12083;Exo1?
FormulaC15H12NO3F
M.Wt273.25908
SMILESO=C(OC)C1=CC=CC=C1NC(C2=CC=C(F)C=C2)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Exo1 is a chemical inhibitor of the exocytic pathway.

In Vitro

Exo1 is a modifier of Golgi ARF1 GTPase activity. Because Exo1 affects a subset of the membrane events that are blocked by BFA, but seems to have a different protein target (and presumably has different side effects), it provides an independent means to interfere with Golgi activity. Exo1 Disrupts Vesicular Traffic from the ER to the Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of ~20 μM. Exo1 prevents acquisition of endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP, transferrin, and MHC class I[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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