DC Chemicals · Product datasheet

Olodanrigan(EMA401) — Datasheet

CAT. NO. DC10869

Product page and current package options

ParameterValue
Chemical NameOlodanrigan free acid
CAS No.1316755-16-4
Synonyms3-Isoquinolinecarboxylic acid, 2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-, (3S)-;EMA 401;EMA-401;EMA401;Olodanrigan;Olodanrigan free acid;P0FN522VTO;Olodanrigan(EMA401);(S)-5-(benzyloxy)-2-(2,2-diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(3S)-2-(2,2-diphenylacetyl)-6-methoxy-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;EMA401; Olodanrigan;Olodanrigan [WHO-DD];GTPL8374;BCP23998;EX-
FormulaC32H29NO5
M.Wt507.59
SMILESO(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])C1=C(C([H])=C([H])C2=C1C([H])([H])[C@@]([H])(C(=O)O[H])N(C(C([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)C2([H])[H])OC([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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