Biological Activity
O-304 is a small molecule AMPK activator.
In Vitro
No in vitro data are provided in the current product source. Contact us for further information.
In Vivo
O-304 efficiently increases glucose uptake and reduces insulin resistance in skeletal muscle a primary cause of obesity-induced T2D. O-304 also reverses β-cell stress/dysfunction and induce β-cell rest. O-304 also increases energy expenditure and protects against diet induced obesity, fatty liver, hyperlipidemia and diabetes. CVD remains a major cause of death of T2 diabetics, and O-304 increases peripheral blood flow and left ventricular function, and acts as an “Exercise mimetic”. Thus, as an AMPK activator O-304 uniquely mitigates many of the metabolic and cardiovascular complications associated with the obesity epidemic. O-304 has the unique potential to increase glucose uptake and reduce insulin resistance in newly diagnosed T2 diabetics and as such prevent the associated β-cell hyperactivity/failure and progression of the disease[1].
References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.