AZD5069 Datasheet | DC10773

AZD5069 — Datasheet

CAT. NO. DC10773

Parameter	Value
Chemical Name	N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
CAS No.	878385-84-3
Synonyms	AZD-5069; AZD 5069; AZD5069,878385-84-3
Formula	C18H22F2N4O5S2
M.Wt	476.51
SMILES	O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.

In Vitro

AZD-5069 (Compound 2) acts as CXCR2 antagonist by inhibition of [125I]-IL-8 binding to human CXCR2 receptors and as inhibitor of GROα-induced Ca2+ flux in human neutrophils loaded with fluo-3 dye[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

125I-IL-8-CXCR2

References & source

[1]. Norman P. Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opin Ther Pat. 2013 Jan;23(1):113-7.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.