DC Chemicals · Product datasheet

Inarigivir(ORI-9020,SB-9000) — Datasheet

CAT. NO. DC10730

Product page and current package options

ParameterValue
Chemical NameInarigivir
CAS No.475650-36-3
Synonyms1-[4-[[5-(6-Aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(hydroxymethy;ORI-9020;SB-9000;2’-O-Methyl-P-thiouridylyl-(3’→5’)-2’-deoxyadenosine;Inarigivir
FormulaC20N7O10PSH26
M.Wt587.5001
SMILESS=P(O[H])(OC([H])([H])C1([H])C([H])(C([H])([H])C([H])(N2C([H])=NC3=C(N([H])[H])N=C([H])N=C23)O1)O[H])OC1([H])C([H])(C([H])([H])O[H])OC([H])(C1([H])OC([H])([H])[H])N1C([H])=C([H])C(N([H])C1=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

I.p. injection of Inarigivir at 100 mg/kg/day significantly reduces viral DNA in the liver and shows anti-HBV activity similar ADV positive control. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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