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Sematilide hydrochloride — Datasheet

CAT. NO. DC10687

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ParameterValue
Chemical NameSematilide hydrochloride; Sematilide HCl; Sematilide hydrochloride; Sematilide; CK-1752A; CK1752A; CK 1752A; CK-1752; CK1752; CK 1752.
CAS No.101526-62-9
SynonymsSematilide hydrochloride; Sematilide HCl; Sematilide hydrochloride; Sematilide; CK-1752A; CK1752A; CK 1752A; CK-1752; CK1752; CK 1752.
FormulaC14H24ClN3O3S
M.Wt349.87
SMILESO=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.[H]Cl
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].

In Vitro

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].

In Vivo

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2]. Animal Model: Mongrel dogs of either sex (10-18 kg body weight)[2] Dosage: 0.3, 1, 3, and 10 mg/kg Administration: I.v. infusions Result: Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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