DC Chemicals · Product datasheet

CNQX — Datasheet

CAT. NO. DC10670

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ParameterValue
Chemical Name6-Cyano-7-nitroquinoxaline-2,3-dione
CAS No.115066-14-3
Synonyms6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-;CNQX;6-CYANO-7-NITROQUINOXALINE- 2,3-DIONE;CNQX Disodium;6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate;6-Cyano-7-nitroquinoxaline-2,3-dione FG-9065;6-Nitro-7-cyanoquinoxaline-2,3-dione;AMPA RECEPTOR;CNOX;CNQX 2NA;CNQX DISODIUM KAINATE;CNQX DISODIUM SALT;CNQX disodium salt hydrate;FG-9065;2,3-Dioxo-7-nitro-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;FG 9065;CNQX (FG-9065) (6-CYANO-7-NITROQUINO;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX DISODIUM KAINATE/AMPA RECEPTOR;7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile;6OTE87SCCW;7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile;1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-;ST50405216;2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;FG9065;[3H]CNQX;Lo
FormulaC9H4N4O4
M.Wt232.1525
SMILESO=C1C(N([H])C2C([H])=C(C#N)C(=C([H])C=2N1[H])[N+](=O)[O-])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.

In Vitro

In rat hippocampal slices bathed in Mg2+-free medium, 10 μM CNQX reversibly blocks responses to a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA[1]. Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition[2]. CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3]. CNQX-mediated depolarizations are mediated by AMPAR but not kainate receptors in TRN neurons[4].

In Vivo

The bilateral infusion of CNQX (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX causes a complete blockade at a dose of 0.5 μg[5].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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